Abstract
The effect of nicotinic acid on lipid profile of albino Wistar rats was investigated to assess its role in the management of lipid related disorder such as dyslipidemia, atherosclerosis and hypertension. Consequently, nicotinic acid at varying pharmacological doses was administered to different groups of albino Wistar rats. This was followed by the examination of the effect on serum total cholesterol (TC), triglyceride (TG), very low density lipoprotein (VLDL), low density lipoprotein (LDL), and high density lipoprotein (HDL). The nicotinic acid was administered to five groups of experimental animals (group B - F) for twenty-one days at the concentrations of 250mg, 500mg, 750, 1000mg and 1250mg per 70kg per day respectively while 'group A' served as the control. The results showed a reduction of TC in all groups when compared to the control. Interestingly, at a dose of 1000mg, there was a significant decrease in TG and VLDL, the percentage composition of HDL increased by 8% when compared to the control. The binding of nicotinic acid to its receptor (HM74/HM74A) is believed to decrease the level of intracellular cyclic AMP thereby inhibiting lipolysis in adipocytes.
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