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Abstract
The protective effect of modified nanodiamonds (MND) under the action of cobalt and nickel ions on the skin of Guinea pigs was shown. At the action of chromium ions on the skin of animals, the protective effect of MND was not found. The differences are related to different adsorption properties of MND to the investigated colored metal ions. It is shown in vitro that MND can adsorb ions of cobalt and nickel and don’t bind ions of chromium from aqueous medium. The perspectives using of MND as a new drug for the prevention allergic dermatitis caused by action of bivalent ions of metals are discussed.
Highlights
At the present time, one of the most common dermatology diseases is Allergic Contact Dermatitis (ACD)
We examined the effects of modified nanodiamonds (MND) at the systematic exposure of cobalt, nickel and chromium ions on the Guinea pigs skin
The results obtained in in vivo experiments show that MND particles have a protecting effect at the action of cobalt and nickel ions on the skin of Guinea pigs, reducing the likelihood of ACD and hampering its development
Summary
One of the most common dermatology diseases is Allergic Contact Dermatitis (ACD). Physical and chemical properties of MND (especially polymorphous chemical active surface of nanoparticles [8] [9] [12]) determine their high adsorption properties of different compounds. This opens prospects for the application of these nanoparticles for the separation and purification of biomolecules [13] [14] [15], immobilization and neutralization of toxins (e.g. mycotoxins) [16] [17], and creation of new systems for biochemical diagnosis [18] and new drug delivery systems [19]
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