Abstract
In order to investigate the possible role of the N-methyl-D-aspartate (NMDA) receptor in the development of the behavioural recovery which occurs following unilateral labyrinthectomy (vestibular compensation) in the guinea pig, we administered systematically the specific NMDA receptor/channel antagonists MK801 and CPP (3-((±)-2-carboxypiperazin-4-yl)-propyl-1-phosphoric acid) during the compensation process. MK801 disrupted the development of ocular motor compensation when administered at 18–22 h post-op (1.0 mg/kg i.p.). CPP had a smaller but still significant disruptive effect when injected at this time (1.0 or 5.0 mg/kg i.p.). We conclude that NMDA receptors may contribute to the development of ocular motor compensation in the guinea pig.
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