Abstract
Objective: To observe the myo-inositol on normal and diabetic rats muscle and intestinal glucose uptake. Methods: The rat jejunum was placed in Kb with containing 2.5% -20% myo-inositol and the glucose concentration was detected at 0 and 2 h. The psoas muscle was placed in Kb containing 2.5% -20% myo-inositol Kb (with or without insulin) the glucose concentration was detected at 0 and 1 h. Rats were divided into blank control group, normal muscle myo-inositol group, blank control group of diabetic rats, myo-inositol group of diabetic rats and acarbose group of diabetic rats (DBA) The intestinal propulsion rate and intestinal absorption of glucose in each group were detected. Results: In vitro studies found that myo-inositol can dose-dependently stimulate the absorption of glucose in the jejunum and promote the uptake of glucose by the psoas muscle in a dose-dependent manner. Myo-inositol can delay gastric emptying in diabetic rats, inhibit intestinal absorption of glucose, reduce postprandial blood glucose in diabetic rats and promote the rate of intestinal propulsion in diabetic rats. Conclusion: Myo-inositol can inhibit the intestinal absorption of glucose in glucose rats and promote the glucose uptake in muscle of normal rats and diabetic rats.
Highlights
There are two major types of diabetes type I and II, of which type 2 diabetes (T2D) is the most common type of diabetes, accounting for more than 90% of all cases of diabetes[1]。Sedentary, high-fat and high-sugar diets, and high intakes of refined sugars and monosaccharides keep the body in high blood sugar for a long time[2]。For the treatment of diabetes, in addition to conventional antidiabetic drug therapy to reduce high-calorie and high-sugar food intake, and the combination of drugs inhibiting an increase in blood sugar after a meal has become more comprehensive diabetes treatment programs [3]。
Myo-inositol, a less used sugar alcohol, is similar in structure to glucose and is found in a variety of foods, but at lower concentrations[4]。D-inositol is another high content of inositol in fat, muscle and liver[5]。 Myo-inositol with glucose transporter activation and glucose utilization,D-inositol is mainly involved in the synthesis of glycogen in liver, fat and muscle tissue [4]。 Studies have found that supplementation with myo-inositol can regulate glucose and lipid metabolism, the glucose and lipid metabolism are closely related to the pathogenesis of T2D. [6]。
2.2 In vivo studies 2.2.1 Effect of Myo-Inositol on Gastric Emptying Compared with diabetic rats given physiological saline, gastric emptying was decreased in diabetic with myo-inositol and acarbose rats (P
Summary
There are two major types of diabetes type I and II, of which type 2 diabetes (T2D) is the most common type of diabetes, accounting for more than 90% of all cases of diabetes[1]。Sedentary, high-fat and high-sugar diets, and high intakes of refined sugars and monosaccharides keep the body in high blood sugar for a long time[2]。For the treatment of diabetes, in addition to conventional antidiabetic drug therapy to reduce high-calorie and high-sugar food intake, and the combination of drugs inhibiting an increase in blood sugar after a meal has become more comprehensive diabetes treatment programs [3]。. Myo-inositol, a less used sugar alcohol, is similar in structure to glucose and is found in a variety of foods, but at lower concentrations[4]。D-inositol is another high content of inositol in fat, muscle and liver[5]。 Myo-inositol with glucose transporter activation and glucose utilization,D-inositol is mainly involved in the synthesis of glycogen in liver, fat and muscle tissue [4]。 Studies have found that supplementation with myo-inositol can regulate glucose and lipid metabolism, the glucose and lipid metabolism are closely related to the pathogenesis of T2D. At present, it is not yet clear whether muscle myo-inositol can affect glucose uptake by muscles, nor does research clearly indicate that myo-inositol can affect intestinal absorption of glucose. This study investigated the effects of muscle inositol on glucose and glucose absorption in muscle and intestine of normal and diabetic rats through in vitro and in vivo studies
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