The effects of mycoplasma pneumoniae infection on the exhaled nitric oxide level and lung function in asthma children

Abstract

Objective To investigate the effects of mycoplasma pneumoniae(MP)infection on the exhaled nitric oxide level and lung function in asthmatic children, analyze the correlation between exhaled nitric oxide level and lung function and to provide reference for the treatment and monitoring of asthmatic children. Methods Sixty-eight children aged from 5 to 13 years old with mild or moderate asthma during June 2011 to January 2013 were collected.MP-IgG antibody, MP-IgM antibody, MP-DNA, total serum IgE, FeNO measurement and spirometry were examined on the next day morning.They were divided into two groups according to the pathogen: ashtma with MP group and ashtma without MP group.Then the levels of nitric oxide level and lung function indicators between the two groups were analyzed. Results The FeNO level in ashtma with MP group was significantly higher(P 0.05), but differnces were found in MEF75 and PEF(P<0.05). No correlation was found between FeNO levels and lung function parameters(FVC, FEV1, FEV1/Vcmax, MEF50, MEF25, MEF75 and PEF). Conclusion In asthma children with MP infection, the FeNO level was significantly increased and no correlation was found between FeNO levels and lung function. Key words: Asthma; Mycoplasma pneumoniae; Exhaled nitric oxide; Lung function