Abstract
The aim of this study was to investigate the mechanisms involved in the immunomodulatory effects of Morinda citrifolia L. (noni) in vitro and in vivo in mice. In vitro, Tahitian Noni ® Juice (TNJ) and Noni fruit juice concentrates (NFJC) (1, 5 mg/mL) potently activate cannabinoid 2 (CB 2), but inhibit cannabinoid 1 (CB 1) receptors in a concentration-dependant manner. In vivo, oral administration of TNJ ad libitum for 16 days decreased the production of IL-4, but increased the production of IFN-γ. These results suggest that noni modulates the immune system via activating of the CB 2 receptors, and suppressing of the IL-4, but increasing the production of IFN-γ cytokines. It may also exert beneficial immunomodulation effects in conditions involving inadequate immune responses.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
