The effects of modifications of lysyl and arginyl groups on the biological and immunological activity of human chorionic gonadotropin

Abstract

Summary Modification of lysine or arginine residues of human chorionic gonadotropin results in a partial loss of immunoreactivity and in a severe loss of biological activity. The arginine and lysine residues of the alpha subunit, but not the beta subunit, are essential for recombination of the subunits to form a biologically active molecule. The determinants on the beta subunit responsible for the formation of a specific anti-beta hCG serum are located at or nearsome of the arginine residues.