Abstract
Lenses were removed from 12-day-old rats and incubated in medium containing 20 μM mirex. Lenses were removed from the medium at 2, 4, 6, and 8 h and assayed for K + and Na + concentrations and hydration. Mirex had no in vitro effect on these lens parameters compared to controls, and produced no changes in lens clarity. In contrast, incubation for 8 h in medium containing 20 μM kepone resulted in elevated lens Na + and lower lens K +. Thus, cataracts induced by mirex in vivo are probably not due to a direct toxic effect on the lens.
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