Abstract
The present study investigated the effects of in vitro methylmercury (MeHg) exposure on endogenous dopamine (DA) efflux from mouse striatal slices. MeHg produced a concentration-dependent increase in the spontaneous efflux of DA which was independent of the availability of Ca 2+ in the superfusion medium. The Ca 2+-dependent K +-evoked release of DA was significantly enhanced by 50 and 100 μM MeHg. This increase could not be solely accounted for by the MeHg-induced increase in spontaneous DA efflux. The K +-stimulated efflux of DA was enhanced by MeHg m both the presence and absence of Ca 2+in the superfusion medium, suggesting that under depolarizing conditions, DA efflux induced by MeHg has a Ca 2+-independent component. The alterations in DA efflux occurred at concentrations of MeHg previously found in the CNS of animals exhibiting symptoms of MeHg intoxication suggesting that alterations in DA neurotransmission in the striatum may contribute to the symptoms of MeHg toxicity.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
