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Abstract
Alterations in frequency distribution of spontaneous brain electrical activity were measured following administration of mescaline, amphetamine, trimethoxy-amphetamine (TMA), methoxy-methylenedioxy-amphetamine (MMDA), methylenedioxy-amphetamine (MDA) and dimethoxy-amphetamine (DMA) to unanesthetized and unrestrained cats. Two orthogonal patterns of frequency change were found which were correlated with dosage of the test compounds. It is proposed that one of these patterns represents central alerting in the cat, while the other is a correlate of the hallucinogenic effect produced in man by some of the drugs used. An analysis of the effects produced by individual compounds for their content of each pattern revealed that only amphetamine produced significant alerting; in terms of hallucinogenic effect, activities of the drugs decreased in the order TMA > MDA > MMDA > mescaline > DMA.
Published Version
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