The Effects of Memantine on Cognitive Function and Pain after Sevoflurane and Desflurane Anesthesia in Streptozotocin Induced Diabetic Rats

doi:10.12996/gmj.2020.35

Abstract

Highlights

Postoperative cognitive dysfunction (POCD) is defined as postoperatively – following anesthesia- emerged regression of cognitive functions such as memory, ability of concentration, language and social communication skills
0.005 p value: achieved from multiple comparisons *: p
Similar to results achieved in diabetic groups, we found higher radial arm maze (RAM) results in memantine treated sevoflurane/desflurane exposed groups than those measured in only inhalation anesthetic administered groups

Summary

Objective

Postoperative cognitive dysfunction (POCD) refers to a wide range of alterations which effect memory, information processing and executive function after anesthesia and, the mechanism is still not properly defined. We aim to investigate the effects of memantine, after sevoflurane and desflurane anesthesia on cognitive dysfunction and pain levels in diabetic rats. In the rat groups of which only variant was memantine (Group DC and Group DM, Group DSM and Group DS, Group DDM and Group DD), we observe that memantine fasten recovery time and has a positive effects on cognitive functions. Conclusion: In conclusion, administration of memantine in diabetic rats has positive effect on recovery, cognitive functions and pain levels after anesthesia with sevoflurane or desflurane. Sadece varyantı memantin olan sıçan gruplarında (Grup DK ve Grup DM, Grup DSM ve Grup DS, Grup DDM ve Grup DD), memantinin iyileşme süresini hızlandırdığını ve kognitif fonksiyonlar üzerinde olumlu etkileri olduğunu gözlemledik. Sonuç: Sonuç olarak, diyabetik sıçanlarda memantin uygulamasının, sevofluran veya desfluran ile anestezi sonrası iyileşme, kognitif fonksiyonlar ve ağrı seviyeleri üzerinde olumlu etkisi vardır.

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