Abstract
The amount and rate of release of Ca 45 from freshly excised rat radii in an oxygenated Krebs-Ringer solution was measured as a function of mechanical stress. The calcium transport process was modeled mathematically by a first-order differential equation and a constraint equation. The solution to these equations, for the radioactivity of the Krebs-Ringer solution surrounding the bone, was fitted to the experimental data using the manimum mean-square error criterion. The constants of the model, which were obtained from this fitting, were used to characterize the effects of the mechanical stress on the transport rates of Ca 45. The results of the experimentation and modeling showed that the application of mechanical stress significantly increased the rate at which calcium entered the bone. This system offers an objective means for studying calcium transport rates in bone in normal and pathological states as well as the effects of hormones and vitamins.
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