Abstract
ABSTRACT Lymphocytes, both living and freeze-thawed, stimulated glycosaminoglycans (GAG) production and glucose utilization by monolayer fibroblast cultures derived from human retrobulbar connective tissue. Freeze-thawed lymphocytes from patients with Graves' disease, most of whom had active ophthalmopathy, were significantly (p < 0.05) more potent in this system than lymphocytes from normal subjects. The stimulating qualities of the lymphocytes could not be related to any clinical feature of the disease. Living lymphocytes from patients did not differ significantly from those of normal individuals in potency to stimulate the retrobulbar fibroblasts. Sera, including LATS containing sera, and IgG fractions of sera containing LATS produced changes in the cultures which were no different than those observed for comparable specimens from normal individuals. Graves' ophthalmopathy, in which accumulations of GAG play a prominent role, may develop from the interaction of lymphocytes and orbital connective tissue...
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