Abstract
The present study investigated the effect of low-level hyperbaric environments on ethanol anesthesia in mice. Drug naive male C57 B1/6j mice were injected i.p. with 3.2 g/kg ethanol (16% w/v). Upon loss of their righting reflex, animals were placed in a hyperbaric chamber and the atmospheric pressure was adjusted to 1, 2 or 4 atmospheres absolute (ATA) with air, 1, 2, 4 or 6 ATA with 100% oxygen or 1, 2, 4 or 6 ATA with a 20% oxygen-80% helium mixture. Tail-vein blood samples were taken upon return of the righting reflex and analyzed for ethanol concentration by gas chromatography.
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