Abstract
The downregulation of synaptic efficacy is referred to as long-term depression (LTD). Recent work has shown that a two-pulse stimulation (TPS) protocol is successful at inducing LTD in vivo in area CA1 of the hippocampus. Here, we examine the ability of two TPS protocols and two low-frequency stimulation (LFS) protocols to induce LTD in the projection from hippocampal area CA1 to the subiculum in the anaesthetized rat. We find no evidence of LTD induction with TPS or LFS protocols. Instead, with three of the protocols (both TPS protocols and 1 Hz LFS), a late-developing potentiation is observed.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
