Abstract
Objective: In this pilot study, given the prevalence of hypertension and panic disorder as described in the literature, we proposed to fill the gaps in the literature on the possible utility of SSRI medication as an adjunct treatment in individuals with panic disorder and hypertension. Methods: We planned to only recruit patients with panic disorder who fit the criteria independently for treatment with SSRI; i.e. treatment would be given based on clinical need and currently accepted Pharmaceutical Benefits Scheme (PBS) criteria. Thereafter, we would monitor their BP at baseline, 14 days and 28 days to determine if there has been an effect on the individual’s BP. Results: Based on the observation above, there may be a trend of a reduction in systolic and diastolic BP after the commencement of sertraline. Conclusion: In order to confirm this observation, a larger sample size is required in the future. This pilot study proposed to meet the objectives as listed below; however due to difficulty with recruitment, only 2 out of 4 participants will be discussed in the analysis.
Highlights
Objectives1) To determine whether Selective Serotonin Re-uptake Inhibitors (SSRI) are a successful adjunct therapy in lowering blood pressure in hypertensive patients
This pilot study proposed to meet the objectives as listed below; due to difficulty with recruitment, only 2 out of 4 participants will be discussed in the analysis
In this pilot study, given the prevalence of hypertension and panic disorder as described in the literature, we proposed to fill the gaps in the literature on the possible utility of SSRI medication as an adjunct treatment in individuals with panic disorder and hypertension
Summary
1) To determine whether Selective Serotonin Re-uptake Inhibitors (SSRI) are a successful adjunct therapy in lowering blood pressure in hypertensive patients. 2) To explore the role of the serotonergic system in regulating systemic blood pressure and panic symptoms. 3) To produce pilot data for submission to the NHMRC/Australian Heart. Foundation project grant and to perform a sample size calculation for a larger trial. Hypothesis: There will be a significant improvement in 1) systolic and 2) diastolic blood pressure in patients with essential hypertension and panic disorder after 28 days of adjunct therapy with an SSRI therapy compared with baseline values
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