Abstract
PURPOSE: The purpose of this study was to investigate the impacts of long-term treadmill exercise on the expression of SPARC and OSM in muscle, blood and colon polyp of colon cancer-induced mice. METHODS: Thirty mice were randomly divided into two groups: Exercise group (EX, n=15), Control group (CON, n=15). Mice of EX, at 6-week of old, performed exercise at moderate intensity for 30 minutes, 5 days per week, during 12 weeks. At 17-week of old, all mice were injected AOM and DSS to induce colon cancer. Then EX kept doing exercise for another 12 weeks. The expression of OSM and SPARC in muscle, blood, colon polyp was analyzed using the ELISA kit. RESULTS: The OSM expression of EX was significantly higher than CON in muscle (p<.01), but not in blood and polyps. On the other hand, the SPARC expression of EX was significantly increased in colon polyp (p<.01) compared with CON, however, there is no significant difference in blood and muscle. CONCLUSIONS: A 24-week treadmill exercise induced over-expression of SPARC and OSM in different tissues of colon cancerinduced mice, therefore these could be one of important factors to demonstrate exercise effect on cancer management.
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