Abstract
In recent years, some investigations have focused on the relationship between gut microbiota and brain function in healthy and disease conditions. Moreover, changes in the gut microbiome may affect memory, behavior, and cognition. This study aimed to evaluate the effect of lactobacilli on passive avoidance learning, hippocampal CaMKII-α, and TNF-α genes expression in one experimental model of neuroinflammtion. Male wistar rats (220-240 g) received daily oral gavage of different lactobacilli including L. rhamnosus, L. reuteri, and L. plantarum for 21 days. At the next step, behavioral test was performed and 4 hours after acute injection of LPS (1mg/kg, ip) retrieval was evaluated. Then the hippocampi were extracted and kept at _80°C. Finally CaMKII-α and TNF-α mRNA levels were evaluated by Real-time PCR. Our results showed that consumption of L. rhamnosus, L.reuteri, or L. plantarum significantly prevented LPS-induced enhancement of TNF-α mRNA and memory deterioration. Furthermore, L. rhamnosus significantly prevented changes induced by LPS on CaMKII-α mRNA levels. It seems the lactobacilli used in this study can affect brain function and memory performance by their immune-modulatory properties.
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