The Effects of Korea Red Ginseng on Inflammatory Cytokines and Apoptosis in Rat Model with Chronic Nonbacterial Prostatitis.

Sang Wook Kang,Chang-Ju Kim,Hae Jeong Park,Je-Hoon Park,Dongwhan Hong,Joo-Ho Chung,Young Sik Kim,Su Kang Kim,Young Rok Han,Young Ock Kim,Hosik Seok

doi:10.1155/2019/2462561

Abstract

Chronic prostatitis typically occurs in aging men, and its symptoms include frequent and painful urination. In recent study, several studies have shown that Korean red ginseng (KRG) can be used in the prevention and treatment of various diseases. The objective of this study is to investigate whether KRG can play a role in repressing the development of chronic nonbacterial prostatitis (CNP) in male Wistar rats. To induce CNP, rats were castrated and beta-estradiol (0.25 mg/kg) was subcutaneously (s.c.) injected daily. 7-week-old male Wistar rats were divided into 5 groups (the normal group, CNP group, positive group, and KRG group (0.25g/kg) and another KRG (0.50g/kg) group. After 4 weeks, all rats were sacrificed and their prostate and serum were analyzed. Compared to the positive group, the KRG groups (0.25g/kg and 0.50g/kg) showed similar protective properties on CNP based on the histopathologic morphology of the prostate and the inflammation cytokines in the prostate tissue. Also, results of the immunohistochemistry staining showed that expression levels of vascular endothelial growth factor A (VEGFA), interleukin 6 (IL6), interleukin 1 beta (IL-1ß), tumor necrosis factor (TNF-alpha), and cytochrome c oxidase subunit II (COX2) were also decreased in KRG group (0.25g/kg) and KRG group (0.50g/kg). These results suggested that KRG inhibited the development of CNP and might a useful herbal treatment or functional food for CNP.

Highlights

Chronic prostatitis is a common disease in aged men [1]
The final body weights in each group (CNP, positive, and Korea red ginseng (KRG) groups) had decreased compared to that in the normal group
Our results showed the effects of KRG on the inflammation and morphology of prostate tissue in case of the chronic nonbacterial prostatitis (CNP)

Summary

Introduction

Chronic prostatitis is a common disease in aged men [1]. The disease causes a diverse range and degree of symptoms, including voiding irritation, pelvic region discomfort, and sexual dysfunctions [2,3,4].Chronic prostatitis is classified as acute, chronic, bacterial, and nonbacterial prostatitis. Chronic prostatitis is a common disease in aged men [1]. The disease causes a diverse range and degree of symptoms, including voiding irritation, pelvic region discomfort, and sexual dysfunctions [2,3,4]. Chronic prostatitis is classified as acute, chronic, bacterial, and nonbacterial prostatitis. More than 90% of all prostatitis patients are affected by chronic nonbacterial prostatitis (CNP) [5]. Despite the high incidence of CNP, the cause of the disease has not been verified, and it is known to be difficult to treat. It is a morbid illness that causes mental dissatisfaction and negatively impacts an individual’s daily quality of life

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