Abstract
The effects of a single intravenous dose of Na iodate on the penetration of 24 Na, 131 I and thiourea into the aqueous humour and vitreous body of the rabbit have been measured. Within a few minutes there is a marked increase in rate of penetration into the vitreous body, the maximal effect being reached within 30–60 min after the injection. Penetration into the posterior segment of vitreous is increased to a much greater extent than into other regions. It is concluded that the site of attack is at the retinal pigment epithelium, increasing its passive permeability characteristics. For comparative purposes, the effects of perchlorate on penetration of 131 I into the eye fluids were measured, since this compound inhibits ciliary body activity. The pattern of altered permeability of the blood-vitreal barrier now conforms with the idea of an exclusive attack on the ciliary body.
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