Abstract
IntroductionThis study aimed to determine the effects of the interaction between intravenous anesthetics and desflurane on the QT interval.MethodsFifty patients who underwent lumbar spine surgery were included. The patients received 3 μg/kg fentanyl and were randomly divided into two groups: group P patients received 1.5 mg/kg propofol and group T patients received 5 mg/kg thiamylal 2 min after fentanyl injection. All patients received rocuronium and desflurane (6% inhaled concentration) after loss of consciousness. Tracheal intubation was performed 3 min after rocuronium injection. Heart rate (HR), mean arterial pressure (MAP), bispectral index score (BIS), and the heart rate-corrected QT (QTc) interval on a 12-lead electrocardiograms were recorded before fentanyl injection (T1), 2 min after fentanyl injection (T2), 1 min after propofol or thiamylal injection (T3), immediately before intubation (T4), and 2 min after intubation (T5).ResultsThere were no significant intergroup differences in patient characteristics. BIS and MAP decreased after anesthesia induction in both groups. MAP values at T3, T4, and T5 in group T were higher than those in group P. HR did not change over time or differ between the groups. The QTc intervals at T4 and T5 in group T were longer than those at T1. In group P, the QTc interval at T3 was significantly shorter than that at T1. The QTc intervals at T3, T4, and T5 in group T were significantly longer than those in group P.ConclusionsA propofol injection could counteract the QTc interval prolongation during desflurane anesthesia induction.Trial registrationUMIN Clinical Trials Registry database reference number: UMIN000023707. This study was registered on August 21, 2016.
Highlights
This study aimed to determine the effects of the interaction between intravenous anesthetics and desflurane on the QT interval
bispectral index score (BIS) and mean arterial pressure (MAP) significantly decreased after anesthesia induction in both groups
There were no significant differences in Heart rate (HR) and QTc dispersion (QTcD) at any recorded time point
Summary
This study aimed to determine the effects of the interaction between intravenous anesthetics and desflurane on the QT interval. QT dispersion (QTD), the difference between the maximum and minimum QT intervals on the 12-lead ECG, is considered a measure of left ventricular repolarization inhomogeneity, which could serve as an electrophysiological index for an increased risk of ventricular dysrhythmia [3]. Our previous study showed that bolus administration of propofol did not affect the QTcD [6]. The aim of this randomized, open-label, clinical study was to determine the effects of the interaction between intravenous anesthetics and desflurane on the QTc interval and QTcD during anesthesia induction
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