Abstract
The effects of 24-hour intracerebroventricular infusion of human atrial natriuretic factor (ANF) and two related fragments were studied in conscious sheep. ANF (1–28) had no effect on either mean arterial pressure (MAP) or heart rate (HR) when infused at 3 or 10 μg/hr, however a small diuresis and an increase in urinary sodium (Na) excretion was observed. The smaller fragment, ANF (5–27) infused at 10 μg/hr, increased MAP, HR and body temperature, although the same rate of infusion of ANF (5–28) was without effect. All peptides increased plasma sodium concentration and plasma osmolality. None of the peptides affected plasma ACTH, glucose or renin concentration. ANF (1–28) had no effect on either Na intake or water intake in Na-depleted sheep. These studies suggest that members of the ANF family can influence a number of physiological functions following central administration.
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