The effects of increased dopamine-levels on attentional control during reading and reading comprehension

Abstract

The aim of the present study was to gain insight into the neurobiological processes, particularly the dopaminergic processes, underlying attentional control during reading and reading comprehension. In order to test the effects of increased levels of dopamine (DA) in the brain, female university students (N = 80), half of them being carriers of the DRD4-7R allele and half of them not, participated in a double-blind placebo-controlled within-subjects experiment in which they were orally administered levodopa or a placebo before reading a text. After reading the text, participants reported on their attentional control during reading and completed comprehension questions. Pharmacologically increasing DA levels in the brain negatively influenced reading comprehension. This effect was moderate (ηp2 = .13). No interaction effects of condition and DRD4 genotype were found, for either attentional control or reading comprehension. Exploratory analyses showed that increased DA levels in the brain positively influenced fluctuations in attentional control, but only in a group of slow readers. No effects of increased DA were found for the two other attentional control measures used in the present study and no effects of increased DA on attentional control were found for fast readers. Results are discussed from the perspective of the inverted U-shape theory and the possible dopamine-related mechanisms.