Abstract

1. 1. Flounder hearts were examined by conventional transmission electron microscopy. Hearts showed clear evidence of a coronary circulation but no intrinsic conduction network or innervation was detected. 2. 2. The box-like cells showed many surface inpocketings and many scattered glycogen granules and membrane bound liposomes. The nucleus position was variable and the cells contained numerous small ovoid mitochondria. 3. 3. Dark staining intercalated discs with clear nexal and desmosomal areas separated individual cells. 4. 4. No organized T-tubular system or sarcoplasmic reticulum was present but the cells displayed abundant surface vesicles which may perform the physiological role of the latter. 5. 5. Hearts of flounder subjected to 3 weeks hypoxia showed striking changes to the mitochondria which were smaller than in controls and there was evidence of increased mitochondria! budding and also evidence of mitochondrial necrosis. 6. 6. Hypoxically-stressed hearts exhibited normal liposome populations but increased glycogen granule deposits. These hearts also showed evidence of myofibril degeneration with torn Z discs and with a build up of fibrous material. 7. 7. It is concluded that the cellular damage seen in hypoxic cells may be due to excessive calcium accumulation or increased catecholamine release.

Full Text
Paper version not known

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.