Abstract
Methods The Ethics Committee approved the study protocol. The contractile response of human IMA (n=6) and SV strips (n = 6) with and without endothelium, suspended in organ baths, bubbled with 95% O2 + 5% CO2 which were subjected to cumulative concentrations of 10-9 – 10-6 M dexmedetomidine were recorded at 37oC and at 28oC. The results were expressed as percentage of maximum contraction to phenylephrine. Statistical Analysis: Contractions induced by dexmedetomidine were expressed as a percentage of phenylephrine induced response. Results are expressed as means ± SD. Student’t test was used for analysis between in groups and results between these groups were determined by unpaired test. A p value of < 0.05 was considered significant.
Highlights
Dexmedetomidine is a a2 agonist, which is used for sedation during and after surgery in patients undergoing CABG
The contractile response of human internal mammarian arteries (IMA) (n=6) and saphenous veins (SV) strips (n = 6) with and without endothelium, suspended in organ baths, bubbled with 95% O2 + 5% CO2 which were subjected to cumulative concentrations of 10-9 – 10-6 M dexmedetomidine were recorded at 37oC and at 28oC
Dexmedetomidine causes in vitro contraction in IMA and SV grafts. These contractions are greater in IMA compared SV strips
Summary
Dexmedetomidine is a a2 agonist, which is used for sedation during and after surgery in patients undergoing CABG. The in vitro effects of moderate hypothermia on dexmedetomidine induced contraction on human internal mammarian arteries (IMA) and saphenous veins (SV) were studied
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