The Effects of Hyperthyroidism on Lipid Peroxidation, Erythrocyte Glutathione and Glutathione Peroxidase

Abdellah Ali,Phalisteen Sultan

doi:10.2478/v10011-010-0048-1

Abstract

The Effects of Hyperthyroidism on Lipid Peroxidation, Erythrocyte Glutathione and Glutathione PeroxidaseThe aim of this study was to determine if lipid peroxidation, glutathione, and glutathione peroxidase levels can be effected by hyperthyroidism. Twenty-three subjects with hyperthyroidism (18 females/5 males), and 19 euthyroid subjects (11 females/8 males) were examined in this study. Plasma and erythrocytes malondialdehyde (MDA), erythrocytes glutathione (GSH) and glutathione peroxidase (GSH-PX) were measured. Results show that an increase in lipid peroxidation was observed in the hyperthyroid patients (p < 0.001). This was accompanied by a decrease in glutathione and glutathione peroxidase in the same subjects (p < 0.001). The results suggest that hyperthyroidism has some effects on lipid peroxidation and free radical scavengers.

Highlights

A free radical is any species capable of independent existence that contains one or more unpaired electrons or a molecule with an unpaired electron in an outer valence shell e.g. oxygen-centered compound (R-O) [1]
Summary: The aim of this study was to determine if lipid peroxidation, glutathione, and glutathione peroxidase levels can be effected by hyperthyroidism
Results show that an increase in lipid peroxidation was observed in the hyperthyroid patients (p< 0.001)

Summary

Introduction

A free radical is any species capable of independent existence that contains one or more unpaired electrons or a molecule with an unpaired electron in an outer valence shell e.g. oxygen-centered compound (R-O) [1]. Oxygen-free radicals or so-called reactive oxygen species (ROS) have important effects on the pathogenesis of tissue damage in several pathologic conditions [2]. Many free radicals have been discovered and described by Haber & Weiss (1934) such as superoxide, hydrogen peroxide, and hydroxyl radical. Namely nucleic acids, amino acids, proteins, lipids, lipoproteins, carbohydrates, and macromolecules of collagen tissue, can be damaged irreversibly or reversibly by free radicals. ROS accumulate in tissues due to intracellular and extracellular processes

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