Abstract
Background The goal of this study was to compare the characteristics of breast cancers and survival rates in HRT users versus nonusers. Methods Data were analyzed for 1055 patients ≥50 years of age who had definitive therapy for breast cancer from 1994 through 2002. Results There were 471 (45%) HRT users. The median age at diagnosis was 61.0 years for HRT users and 68.0 years for HRT nonusers ( P < .001). HRT users more often had tumors that were <1 cm ( P = .007), node negative ( P = .033), and grade I ( P = .016). HRT users had a decreased risk of death versus nonusers (hazard ratio = .438, 95% confidence limit = .263 to .729, P = .002). Conclusions HRT users developed breast cancer at a younger age than nonusers; HRT use was associated with the development of biologically more favorable cancers than those that developed in nonusers; and overall and disease-free survival rates were higher in HRT users than nonusers.
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