The effects of Honey and Aloe Vera extract on Ibuprofen Induced Liver Damage in rats.

Abstract

This study was designed to determine the effect of Aloe Vera extract and honey against ibuprofen induced liver damage in albino rats. A total of twenty five (25) adult male albino rats weighing 100-150g were divided into five groups (I, II, III, IV and V) of five rats each. Rats in group I served as control and were administered normal saline in a volume equivalent to the highest dosed group, rats in group II were administered 100mgkg -1 of ibuprofen, rats in group III were administered 100mgkg -1 of ibuprofen and 10 gkg -1 of Aloe Vera extract , rats in group IV were administered 100mgkg -1 of ibuprofen and 10 gkg -1 of honey while rats in group V were administered with 100mgkg -1 of ibuprofen , 10 gkg -1 of Aloe Vera extract and 10 gkg -1 of honey orally. The result showed a slight increase in liver weight, a significant increase (P<0.05) in the levels of Aspartate minotransferases (ASAT) , Alanine aminotransferases (ALAT) and Alkaline phosphatase (ALP) in the ibuprofen treated rats when compared to the control rats. Administration of Aloe vera extract and honey did not reverse the damage caused. Histological findings indicate severe dilation of blood vessel, necrosis of vascular connective tissues, wide spread vacuolar degeneration, edema and bile duct hyperplasia. The result indicates that Aloe vera extract and honey has little or no effect in preventing ibuprofen induced toxicity.