Abstract
In a series of articles appearing during the last two years, attention has been called to the marked pressor effects of the guanidin compounds and to the possibility that these compounds or allied substances may play a role in arterial hypertension. In addition to these observations on the pressor activity of guanidin, the action of various substances that lower this experimental hypertension has been studied. We have studied the effect of such substances as calcium chlorid, potassium chlorid, ammonium chlorid and hydrochloric acid, as well as the action of various tissue extracts, particularly those obtained from the thyroid, testis, ovary, muscle, parathyroid and liver on this hypertension. As a logical sequence of this work the effect of some of these substances on arterial hypertension in man has been investigated, and some interesting results have been observed. Some striking effects were obtained by the use of tissue extracts, particularly those of
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