Abstract
Rheumatoid Arthritis (RA) has been the most disease that recorded high number in Iraqi population, Interleukin-4 (IL-4) have been reported to associate with pathogenesis of rheumatoid arthritis (RA); which it is role of IL-4 genetic polymorphisms in RA. Method: A total of 50 unrelated IRAQ patients with RA and 40 healthy Iraqi volunteers with no family histories of any autoimmune diseases were recruited. The promoter IL-4-590 C/T  polymorphisms were genotyped gene polymorphism implemented used RFLP technique. Result:The results show The genotype distributions and allele frequencies of IL-4-590 C/T  polymorphisms in RA patients were significantly different from healthy Statistically significant differences were observed in genotypes for IL-4-590 .The frequencies of the T allele on the IL- 4-590 were significantly increased in RA patients. Conclusion. The IL-4-590  promoter polymorphisms may be associated with increased risk of RA and could be used as genetic marker for assessing the susceptibility and severity of RA in Iraqi.
Highlights
IntroductionRheumatoid arthritis (RA) is a disease of autoimmune disease that causes hope Worm in the joints and chronic inflammatory related with progressive disability, In autoimmune disease, a device begins Immune to your healthy tissues In the case of rheumatoid arthritis, complications in some systems , early death , previous studies show that it was 0.5 to 2% of the world’s population [1]
Rheumatoid arthritis (RA) is a disease of autoimmune disease that causes hope Worm in the joints and chronic inflammatory related with progressive disability, In autoimmune disease, a device begins Immune to your healthy tissues In the case of rheumatoid arthritis, complications in some systems, early death, previous studies show that it was 0.5 to 2% of the world’s population [1].RA pathogenesis refer to secration many of the pro-inflammatory cytokines such as IL4,IL6 and ather [2, 3]
The results of present study show that the demographic distribution was shown in table (1), the age means were 47.5±12.48for control and 38±10.37 for patients according to sex female more than male in patients with significant increment, male percentage was 35%, 18% in control and patients respectively and female percentage was 65%, 82% in control and patients respectively, this results deal with international studies that improved that female was more susceptible to the disease than male, this may be because the difference of hormonal activity between male and female the deference's of behavior and life style (12,13)
Summary
Rheumatoid arthritis (RA) is a disease of autoimmune disease that causes hope Worm in the joints and chronic inflammatory related with progressive disability, In autoimmune disease, a device begins Immune to your healthy tissues In the case of rheumatoid arthritis, complications in some systems , early death , previous studies show that it was 0.5 to 2% of the world’s population [1]. A single-nucleotide polymorphism of ccr was found to be associated with susceptibility to rheumatoid arthritis in Japanese and Taiwanese population [5, 6]. Many cytokine genes were playing an important role in its pathogenesis [7]. Interleukin-4 (IL-4) and interleukin-6 (IL-6) are the two most important cytokine genes associated with RA [8, 9]. IL-4 is the first discovered B-cell pleiotropic cytokine that promotes proliferation of T cells and antibodies production of B cells and plays an important role in the immune system [10, 11]. IL-4590 promoter polymorphism, a C-to-T base substitution, has been suggested to be associated with RA, especially with early pauciarticular juvenile rheumatoid arthritis [13]. Many previous studies examined the association of IL-4 gene polymorphisms with RA [14], but their data are conflicting, so the association of IL-4 gene polymorphisms with RA in Iraq could not be deduced and needs further studies
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