The Effects of GABA-Rich Adzuki Beans on Glycolipid Metabolism, as Well as Intestinal Flora, in Type 2 Diabetic Mice.

Aiwu Zhang,Dongmei Cao,Dongjie Zhang,Xiujie Jiang,Qingpeng Xu,Zhijiang Li,Yunfei Ge,Huacheng Tang

doi:10.3389/fnut.2022.849529

Abstract

ObjectivesIn this study, the effects of γ-aminobutyric acid (GABA)-rich sprouted adzuki beans on the glycolipid metabolism and gastrointestinal health were investigated in mice with type 2 diabetes mellitus (T2DM).MethodsMice with T2DM were subjected to dietary intervention with different doses of GABA-rich sprouted adzuki beans for 6 consecutive weeks, during which growth indicators, glycolipid metabolism, and the composition and diversity of the gut microbiota changes were observed.ResultsA high dietary intake of GABA-rich sprouted adzuki beans had a preventive effect against weight gain, significantly reduced serum levels of FBG, TG, and TC. Additionally, high dietary intake of GABA-rich sprouted adzuki beans increased the abundances of Firmicutes, Bacteroidetes, Verrucomicrobia, and Akkermansia, leading to a shift in the structure of the gut microbiota toward the dominance of probiotics with regulatory effects on glycolipid metabolism.ConclusionsGABA-rich sprouted adzuki beans can effectively control the bodyweight of mice with T2DM, maintain a balanced blood glucose level, improve glycolipid metabolism and the changes in the microbiota may mediate the anti-diabetic effect of sprouted adzuki beans.

Highlights

Diabetes is a metabolic disease, the pathophysiology is linked to insulin levels in the body and the body’s ability to use insulin
The goal of this study is to discover the regulatory effects of dietary intervention with GABA-rich sprouted adzuki beans on the glycolipid metabolism and gut microbiota in T2DM mice, providing a technical guide for the development of GABA-rich functional, sprouted foods capable of regulating glycolipid metabolism
At week 11, BW was considerably higher in the M group than in the C group and considerably lower in the TF3, TG, and TS groups than in the model (T2DM) group (p < 0.05), implying that dietary intervention with GABA-rich sprouted adzuki beans and oral administration of GABA (TG) and metformin (TS) can reduce BW in mice with T2DM, with a preventive effect against weight gain (Figure 1A)

Summary

Introduction

Diabetes is a metabolic disease, the pathophysiology is linked to insulin levels in the body and the body’s ability to use insulin. Type 1 diabetes is characterized by a complete lack of insulin, whereas type 2 diabetes is characterized by peripheral tissue resistance to the effects of insulin [1]. Type 2 diabetes (T2DM) is a chronic metabolic disease characterized by abnormal insulin secretion or defective insulin action. It is characterized by impaired glucose metabolism disorders, local hyperglycemia, as well as impaired lipid and protein metabolism [2]. According to data issued by the International Diabetes Federation (IDF), the global diabetes population reached 463 million in 2019, with nearly 90 percent of them suffering from T2DM.

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