Abstract
Objective To investigate the efficacy of frontal rhytidectomy by different injection site of botulinum toxin type A on sebum secretion and quality. Methods Thirty-two volunteers with forehead ryhtides(moderate to severe) were received frontal rhytidectomy by BTX-A (BOTOX) intramuscular injection which was administered to 5 injective sites, and randomly divided into 2 groups according to different injection site (Dermal injection group and muscle injection group). Baseline and post-treatment (2, 4, 6, 8 weeks after injection) sebum production (the region 0.5 cm far around injection point, the region 0.6-1.5 cm far around injection point) and elasticity were measured. Results Significant reduction of sebum secretion was showed on the regions of 0.5 cm far around injection point and 0.6-1.5 cm far around injection point after BTX-A injection for 4, 8 weeks (P 0.05). Conclusions Intramuscular injection of BTX-A could reduce the sebum secretion of the region 1.5 cm far around the injection point after 4 weeks and 8 weeks treatment, and increase the elasticity after 4 weeks treatment. Key words: Botulinum toxins/TU; Rhytidoplasty; Sebaceous glands/SE; Skin
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