Abstract
Extracellular excitatory postsynaptic potentials (EPSPs) were recorded from the stratum radiatum of CA1 of the rat hippocampal slice. The effect of altering the external Ca concentration was studied on the amplitude of the low frequency evoked EPSP preceeding and following the production of long-term potentiation (LTP). The double logarithmic plot of the relationship between the EPSP amplitude and external Ca had a maximum slope of 2.1, implying Ca cooperativity in transmitter release. The production of LTP did not alter the slope. The amplitude of LTP was found to be highly dependent on the external Ca concentration, with LTP increasing from a 5% increase in the EPSP amplitude in 0.8 mM Ca, to a 65% increase in the EPSP amplitude in 2.0 mM Ca.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
