Abstract
BackgroundAsthma and obesity are public health problems with increasing prevalence worldwide. Clinical and epidemiologic studies have demonstrated that obese asthmatics have worse clinical control and health related quality of life (HRQL) despite an optimized medical treatment. Bariatric surgery is successful to weight-loss and improves asthma control; however, the benefits of nonsurgical interventions remain unknown.Methods/DesignThis is a randomized controlled trial with 2-arms parallel. Fifty-five moderate or severe asthmatics with grade II obesity (BMI ≥ 35 kg/m2) under optimized medication will be randomly assigned into either weight-loss program + sham (WL + S group) or weight-loss program + exercise (WL + E group). The weight loss program will be the same for both groups including nutrition and psychological therapies (every 15 days, total of 6 sessions, 60 min each). Exercise program will include aerobic and resistance muscle training while sham treatment will include a breathing and stretching program (both programs twice a week, 3 months, 60 min each session). The primary outcome variable will be asthma clinical control. Secondary outcomes include HRQL, levels of depression and anxiety, lung function, daily life physical activity, body composition, maximal aerobic capacity, strength muscle and sleep disorders. Potential mechanism (changes in lung mechanical and airway/systemic inflammation) will also be examined to explain the benefits in both groups.DiscussionThis study will bring a significant contribution to the literature evaluating the effects of exercise conditioning in a weight loss intervention in obese asthmatics as well as will evaluate possible involved mechanisms.Trial registrationNCT02188940
Highlights
Asthma and obesity are public health problems with increasing prevalence worldwide
This study will bring a significant contribution to the literature evaluating the effects of exercise conditioning in a weight loss intervention in obese asthmatics as well as will evaluate possible involved mechanisms
The association between asthma and obesity is an interesting issue since the pathogenesis of asthma is altered in obese asthmatics because they do not respond as well to standard controller asthma therapy
Summary
Asthma and obesity are public health problems with increasing prevalence worldwide. Clinical and epidemiologic studies have demonstrated that obese asthmatics have worse clinical control and health related quality of life (HRQL) despite an optimized medical treatment. Asthma is a chronic respiratory disease characterized by episodes of reversible airway obstruction, chronic airway inflammation and airway hyperresponsiveness. Asthma affects approximately 300 million people worldwide and is expected to affect an additional 100 million people by 2025 [1, 2]. Obesity is characterized by excess fat accumulation in the body as a result of a complex interaction among genetics, dietary caloric intake and energy expenditure and is often diagnosed in adults with a BMI ≥ 30.0 kg/m2 [5]. The prevalence of obesity is highest in WHO Regions of America (27 % of obesity) and lowest in the WHO Regions for South East Asia (5 % of obesity) [6]
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