Abstract
ObjectiveSynthetic adhesives are used by various medical specialties, especially in surgery; however, studies reporting their use in orthopedic practice are scarce. The aim of this study was to compare the results in using ethyl-2-cyanoacrylate or butyl-2-cyanoacrylate in the treatment of fractures in rats. MethodsThis was an experimental prospective controlled study in 90 rats, with humerus, femur, and tibia fractures, treated with ethyl-2-cyanoacrylate (SB group; n=45) or butyl-2-cyanoacrylate (HA group; n=45). Biomechanical and histomorphometric analyses were performed at three different moments (60, 120, and 180days); besides a clinical study performed weekly by measurement of the animals body mass. ResultsNo differences were observed regarding body mass (p=0.07). In both groups, there were no significant differences regarding maximum load (p=0.6), yield point strength (p=0.6), and stiffness coefficient (p=0.4) of the femurs. The same was observed in tibias for maximum load (p=0.4), yield point strength (p=0.7), and stiffness coefficient (p=0.6). The humerus from both groups had similar bone callus area (p=0.66). In both groups, there were no statistical differences related to inflammatory cells (p=0.4), osteoblasts (p=0.2), and osteoclasts (p=0.2). ConclusionEthyl-2-cyanoacrylate was more effective than butyl-2-cyanoacrylate in the treatment of fractures in rats.
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