Abstract
The free‐running period of the endogenous rhythm of swimming activity shown by Corophium volutator is unaffected by sea water solutions of ethanol in the 0.001 to 0.05% range but phase delays of up to 130 minutes are observed. The observed phase shift occurs within the first few hours after transfer and the magnitude of the changes is unrelated to the ethanol concentration. The ionophore valinomycin also induces a phase delay, the magnitude of which is inversely proportional to the concentration of the reagent. Phase response curves for ethanol and valinomycin have been calculated following pulsed application of the drugs. Ethanol applied during the early ebb induces a phase delay of about 90 minutes while similar treatment at the time of low water advances the rhythm by 30 minutes. Valinomycin pulses induce phase shifts which are opposite in sign to those produced by ethanol alone. The effects of cyclohexamide are more equivocal, the rhythm persisting in dilute solutions but attenuating rapidly in higher...
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