The Effects of Ethanol Extract, Chayote (Sechium Edule (Jacq.) Swartz) Fraction and Juice on the High-density Lipoprotein Level in Male White Mice

Abstract

Background: Cholesterol imbalance occurs in Diabetes Mellitus, where high-density lipo­protein (HDL) levels are low and low-density lipoprotein (LDL) increases, where this im­balance results in the appearance of athero­sclerosis. HDL has antiarterosclerotic poten­tial so it needs to be targeted for therapy. One of the bioactive compounds that have this effect is found in chayote ( Sechium edule (Jacq.) Swartz). This study aimed to examine the effects of ethanol extract, Chayote ( Sechium Edule (Jacq.) Swartz) fraction and juice on the hdl level in male white mice Subjects and Method: A randomized controlled trial study was conducted to test HDL level in 54 male white rats of the Wistar strain ( Rattus novergius sp .) after received ethanol extract, Chayote ( Sechium Edule (Jacq.) Swartz ) fraction and juice. The depen­dent variable was the HDL level. The indepen­dent variable was the variation in the dose of ethanol extract, fraction and Sechium edule ( Jacq.) Swartz Juice. The data were analyzed using Anova test. Results: The treatment group induced by Streptozotocin 50 mg / kgBW + nicotinamide (120 mg/kgBW) + HFD and obtained ethanol extract of chayote fruit 150 mg / kgBW, orally had the highest average HDL levels compared to other groups (Mean = 17.31; SD = 3.14). Conclusion : The ethanol solvent found in the ethanol extract is better because it attracts biaoctive compounds so that it has a better effect than the ethyl acetate fraction and the n-hexane fraction. Conclusion: The ethanol solvent found in the ethanol extract is better because it attracts biaoctive compounds so that it has a better effect than the ethyl acetate fraction and the n-hexane fraction. Keyword s : HDL, Flavonoid, Sechium edule (Jacq.) Swartz Correspondence: Jekson Martiar Siahaan. Department of Physiology, Faculty of Medicine, Universitas Methodist Indonesia. Jl. Setia Budi Pasar II Tj. Sari, Medan 20132, North Sumatera. Email: jekson.siahaan.sked@gmail.com Indonesian Journal of Medicine (2021), 06(02): 145-151 https://doi.org/10.26911/theijmed.2021.06.02.03