Abstract
SUMMARYOur study was designed to test the hypothesis that the epileptiform activity of chronically isolated cortex is due to supersensitivity to endogenous acetylcholine. Eserine and atropine were administered systemically to cats with chronically isolated occipital cortex and implanted EEG recording electrodes. Eserine usually diminished the amplitude and increased the duration of the epileptiform EEG discharges in the isolated area. These changes were antagonized by a subsequent administration of atropine. Atropine, without a preceding application of eserine, did not abolish the paroxysmal discharges but tended to obscure them by inducing slow waves in the island. In contrast, diazepam was very effective in abolishing the paroxysmal discharges. The effects of both eserine and atropine on the paroxysmal activity of the island occurred only at those dosage levels that produced changes in the EEG from other areas of the brain. These results do not support the hypothesis investigated.
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