Abstract
Summary Varied doses of E. coli endotoxin were administered to calves by intravenous, subcutaneous and oral routes. The dosage necessary to produce clinical signs and death differed considerably in individual calves. Susceptibility of calves to E. coli endotoxin did not correlate directly with the presence or absence of circulating antibodies. The gross lesions and histological fadings resembled those which occur in natural and experimental colibacillosis, and bore a close resemblance to those described in calves in association with anaphylactic shock. It is postulated that hypersensitivity and anaphylaxis may play a part in the pathogenesis of colibacillosis in calves.
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