Abstract
AbstractPharmaceuticals and personal care products constitute one of the most common groups of contaminants in surface waters, and little is known about their impact on aquatic wildlife. The antidepressant fluoxetine is among more prevalent categories of pharmaceuticals detected in the aquatic environment. Typical surface water concentrations are in a wide range that can lead to alterations in life of aquatic macroinvertebrates. Because the mode of fluoxetine action is thought to be by modulation of the neurotransmitter serotonin, macroinvertebrates that possess relevant transporters and receptors sensitive are potentially affected by this pharmaceutical. Available information of how this emerging contaminant may affect macroinvertebrate communities is limited. This review describes the influence of pharmaceuticals on aquatic fauna in general and reports the environmental concentrations of some widely used antidepressants. Additionally, we highlighted the effects of fluoxetine as an antidepressant of concern, because of its abundance and potential for toxicity to aquatic macroinvertebrates.
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