Abstract
Micron-size gas bubbles are intravenously injected into patients body at the time of ultrasound imaging to improve image contrast. The bubbles are encapsulated by a thin layer (4–10 nm) of protein, lipids, and other surface active materials, to prevent their premature dissolution in the blood. We will present a model for the dissolution of the microbubble that accounts for the effects of encapsulation. The encapsulation hinders the permeability of the gas-liquid surface and its elasticity balances the surface tension-induced stress. Both these effects will be explicitly modeled. The model behavior will be discussed for variations of the material parameters and conditions (encapsulation permeability and elasticity, mole fraction of the osmotic agent and liquid saturation). The encapsulation significantly affects the bubble growth and dissolution including their time scales.
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