Abstract
Rats were administered 100 mg/kg of p-chlorophenylalanine (PCPA) or saline daily from birth until 18 days of age. At weaning (28 days), half of each group was assigned to either an enriched or isolated environmental condition until approximately 80 days of age. A significant drug by environment interaction was found in the analysis of serotonin (5-HT) whole brain levels, which was not related to open field activity, but was related to a shock-induced active avoidance task. Conditions which decreased 5-HT levels also increased the number of active avoidance responses. The importance of rearing conditions between early drug manipulation and adult testing is discussed.
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