Abstract
This study aimed to investigate the effect of diet and dose on the pharmacokinetics of omeprazole in the horse. Six horses received two doses (1 and 4mg/kg) of omeprazole orally once daily for 5days. Each dose was evaluated during feeding either a high-grain/low-fibre (HG/LF) diet or an adlibitum hay (HAY) diet in a four-way crossover design. Plasma samples were collected for pharmacokinetic analysis on days 1 and 5. Plasma omeprazole concentrations were determined by ultra-high pressure liquid chromatography-mass spectrometry. In horses being fed the HG/LF diet, on day 1, the area under the curve (AUC) and maximal plasma concentration (Cmax ) were higher on the 4mg/kg dose than on the 1mg/kg dose. The AUC was higher on day 5 compared to day 1 with the 4mg/kg dose on the HG/LF diet. On days 1 and 5, the AUC and Cmax were higher in horses being fed the HG/LF diet and receiving the 4mg/kg dose than in horses being fed the HAY diet and receiving the 1mg/kg dose. These findings suggest that both dose and diet may affect pharmacokinetic variables of omeprazole in the horse.
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