Abstract
The effects of the dopamine D1 and D2 receptor agonists SKF and TNPA and the antagonists SCH 23390 and raclopride on the behavior of rats making different choices of reinforcement value were studied. Animals were separated into two typological groups – a group of impulsive animals, selecting low-value immediate reinforcement, and a group of self-controlled animals, preferring a valuable but delayed reinforcement (the delay-discount paradigm). Our results showed that systemic administration of D1 and D2 receptor antagonists SCH 23390 and raclopride led to increases in choosing the pedal delivering the immediate low-value reinforcement only in self-controlled animals. All animals showed increases in the numbers of missed reactions. Administration of the D1 and D2 receptor agonists SKF and TNPA produced differently directed and insignificant changes in reinforcement delivery pedal selection – self-controlled rats showed a decrease in the number of presses on the pedal delivering the valuable delayed reinforcement, while impulsive animals, conversely, showed an increase in the number of presses on the pedal delivering the more valuable reinforcement. Thus, these results provide evidence that changes in dopamine levels have different effects in animals with different individual-typological characteristics.
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