Abstract
Background The methylation status at the human papilloma virus (HPV) genome found in pre-invasive and invasive cervical lesions suggests that neoplastic transformation can be suppressed by gene hypermethylation, whereas hypomethylation accompanies or causes cancer progression; hence, epigenetic therapy aimed at reactivating cellular suppressor-gene expression has the potential to act as a tumor promoter by enhancing HPV oncoprotein expression in HPV-related malignancies. The objective of this study was to determine the influence of hydralazine and valproate on HPV oncogene expression in cervical cancer cell lines and the primary tumors of patients undergoing treatment with hydralazine and valproate.
Highlights
Epigenetic aberrations such as alterations in DNA methylation are a common hallmark of cancer
We analyzed the effects of DNA methylation and histone deacetylase inhibitors upon the human papillomavirus early genes expression in cervical cancer cell lines and patients
Our results demonstrate that hydralazine and valproate induce growth inhibition in cervical cancer cells without causing significant changes in the expression level of E6/ E7 transcript
Summary
The effects of DNA methylation and histone deacetylase inhibitors upon the human papillomavirus early genes expression in cervical cancer. Erik de la Cruz-Hernandez, Adriana Contreras-Paredes, Alejandro Mohar, David Cantú, Marcela Lizano and Alfonso Duenas-Gonzalez*1. Address: 1Unidad de Inv. Biomédica en Cancer, IIB, UNAM/INCAN, Mexico and 2Department of Gynecology, INCAN, Mexico. Published: 5 February 2007 BMC Cancer 2007, 7(Suppl 1):A25 doi:10.1186/1471-2407-7-S1-A25. islen2t4iilathbleohr>erAelso.s-lores Gallardo-Rincon, Luis A Herrera, Myrna Candelaria, Adolfo Fuentes-Alburo Meeting abstracts – A single PDF containing all
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