Abstract
PurposeThis study aimed to assess the effect of diurnal intermittent fasting (DIF) during and outside of the month of Ramadan on plasma levels of interleukin (IL)-1β, IL-6, and IL-8, while controlling for sleep/wake pattern, sleep length and quality, meal composition, energy consumption and expenditure, and light exposure. DIF outside of the month of Ramadan was performed to evaluate the effect of DIF in the absence of the way of life accompanying Ramadan.MethodsTwelve healthy male volunteers with a mean age of 25.1 ± 2.5 years arrived to the sleep laboratory on 4 times: 1) adaptation, 5 weeks before Ramadan; 2) 4 weeks before Ramadan while performing DIF for 1 week (fasting outside of Ramadan; FOR); 3) 1 week before Ramadan (non-fasting baseline; non-fasting BL); and 4) After completing 2 weeks of Ramadan while performing DIF. Plasma levels of cytokines were assessed using enzyme-linked immunoassays at 22:00, 02:00, 04:00, 06:00, and 11:00.ResultsDuring DIF, there was a significant decrease in the levels of cytokines, particularly, IL-1β and IL-6, in most measurements compared to non-fasting BL. This reduction was more obvious during the FOR period. There were no significant changes in the circadian phase of the measured cytokines reflected by the acrophase of the measured variables during fasting (FOR and Ramadan) compared to non-fasting BL.ConclusionUnder controlled conditions, DIF led to significantly decreased plasma levels of cytokines (IL-1β, IL-6, and IL-8), particularly IL-1β and IL-6 across 24 h. DIF had no effect on the circadian patterns of the measured cytokines as shown by cosinor analysis.
Highlights
Great interest had been developed on the effect of intermittent fasting on cadriometabolic risk, diurnal intermittent fasting (DIF) [1]
During DIF, there was a significant decrease in the levels of cytokines, IL-1β and IL-6, in most measurements compared to non-fasting BL
There were no significant changes in the circadian phase of the measured cytokines reflected by the acrophase of the measured variables during fasting (FOR and Ramadan) compared to non-fasting BL
Summary
Great interest had been developed on the effect of intermittent fasting on cadriometabolic risk, diurnal intermittent fasting (DIF) [1]. During Ramadan DIF, fast performers abstain from food, drinks, and smoking from dawn to sunset for a period of one month. 2 main meals are taken at night during Ramadan; the first after sunset and the second before dawn, where performers usually obtain adequate sleep at night before the predawn meal [3]. This practice has a religious dimension that aims to motivate performers to rise early, before dawn, for the pre-dawn meal and dawn prayer. Data from studies assessing the health effects of CR or other types of fasting cannot be extrapolated to the Ramadan DIF [1]
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