Abstract

The experiment compared the effects of a known hallucinogenic agent, mescaline, and a compound found in the urine of schizophrenics, 3,4-dimethoxyphenylethylamine, on a classically conditioned behavior, the potentiated startle response in rats. The results indicated that both compounds are excitatory in terms of the behavioral parameters investigated. It was noted that in previous research using instrumentally conditioned behavior both compounds have proven to be inhibitory. The present experiment also investigated the effects of a known stimulant, d-amphetamine which also proved to have an excitatory effect. However, it was noted that this compound also has an excitatory effect on instrumentally conditioned behavior. It was suggested that instrumentally and classically conditioned behaviors are fundamentally different forms of behavior, perhaps mediated by different parts of the nervous system, and that drug effects may be dependent upon the form of behavior used in the investigation.

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