Abstract
The effects of different doses of oral creatine supplementation on tibial muscle resistence and fatigue in wistar rats
Highlights
Dietary supplementation with various types of nutrients is popular and widely used, mainly by athletes
It is believed that Cr can help the maintenance of high energy phosphate during exercise, increasing performance in several activities such as high intensity exercises, repeated tasks of intensity with frequent pauses, more prolonged anaerobic tasks, and sports activities of endurance, increasing creatine phosphate (PCr) stocks, and leading to a higher ATP resynthesis capacity (ARAÚJO et al, 2013; PERSKY; BRAZEAU, 2001; RICO-SANZ, 2000)
The current study aimed to evaluate the effect of supplementation with several doses of creatine monohydrate (Crm), a "physiological storer" of energy, on localized muscular fatigue, and demonstrate the best dose, using for this purpose the experimental model of tetanic contractions induced by indirect electrostimulation of the tibial muscle of rats
Summary
Dietary supplementation with various types of nutrients is popular and widely used, mainly by athletes. The consumption of these nutritional supplements is a phenomenon which has been growing. The use of creatine (Cr) as a food supplement is being studied in several fields of healthcare and with different subjects such as elderly people, sick people, athletes, and people who practice exercises (ZANELLI et al, 2015). The effectiveness of Cr in the increase in corporal mass, performance in exercises of high intensity and exercises of short duration has been confirmed, showing it to be one of the most popular supplements in the world (BRANCH, 2003). Creatinesupplemented rats demonstrate antioxidant and protective effects, decreasing reactive oxygen species (ROS) when compared with rats without supplementation
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