Abstract
Purpose: Marrow adipose tissue (MAT) expansion and associated lipotoxicity are important drivers of age-related bone loss and hematopoietic bone marrow (HBM) atrophy. Fish oil and borage oil (rich in ω3 fatty acids) can partially prevent aged-related bone loss in SAMP8 mice. However, whether preservation of bone mass in this progeria model is associated with MAT volumes remains unknown.Results: MAT volume fraction (MAT%) showed a negative association with hematopoietic bone marrow (HBM%;r=-0.836, p<0.001) and bone (bone%;r=-0.344, p=0.013) volume fractions.Adjusting for multiple comparisons, bone% was higher and MAT% was lower in Fish oil (FO)-supplemented groups vs. controls (p<0.001). HBM% did not differ significantly between the four groups. However, in the group supplemented with FO, HBM comprised higher fractions and MAT constituted lower fractions of total marrow vs. controls (p<0.001).Conclusion: Feeding FO-enriched diet prevented age-related bone and HBM loss, by reducing MAT expansion. Our results further emphasize on the role(s) of MAT expansion in bone and HBM atrophy.Methods: SAMP8 mice (n>9 /group) were allocated into 4 categories and fed a control ration, FO-, sunflower oil (SFO)- and borage oil-enriched diets for lifetime. Femurs were scanned using microcomputed tomography (μCT) and bone, MAT, and HBM volumes were determined using an image analysis software.
Highlights
Marrow adipose tissue (MAT) accumulation and the associated marrow lipotoxicity has been suggested as a major cause of bone and red marrow volume decline in humans and animals [1,2,3,4,5]
Adjusting for multiple comparisons, bone% was higher and MAT% was lower in Fish oil (FO)-supplemented groups vs. controls (p
It has previously been shown that lifelong diets supplemented with fish oil (FO) and borage oil can partially curtail age-related bone loss in senescence accelerated mouseprone 8 (SAMP8) mice, that interestingly coincided with decreased levels of inflammatory markers [10]
Summary
Marrow adipose tissue (MAT) accumulation and the associated marrow lipotoxicity has been suggested as a major cause of bone and red marrow volume decline in humans and animals [1,2,3,4,5]. It has previously been shown that lifelong diets (starting at the young age and continuing till the end of life) supplemented with fish oil (FO) and borage oil (both rich www.aging-us.com in ω3 [n-3] fatty acids) can partially curtail age-related bone loss in SAMP8 mice (a progeria animal model), that interestingly coincided with decreased levels of inflammatory markers [10]. It is unknown whether preservation of bone mass in this progeria model is accompanied by reduced MAT volume. We hypothesized that higher bone volume seen in feeding fatty acids in the SAMP8 mice is associated with low MAT and high HBM volumes
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