Abstract
Lipoprotein lipase (LPL) has been much studied since the discovery by Hahn et al., in 1943, of the LPL activity, which they called the “clearing factor”1. Later Korn investigated and characterised this enzyme2, and his work was further expanded by Robinson et al.3 In early studies in man a relationship was found between LPL activity (LPLA) in adipose tissue and the serum triglyceride concentration4. The relative importance of adipose tissue and muscle tissue for the regulation of the catabolism of triglycerides in chylomicrons and very low density lipoproteins (VLDL) was first investigated by Rossner5. Using infusion of IntralipidR as a model for the catabolism of triglyceride-rich lipoproteins in man, he found that almost half of the hydrolysis took place in muscle tissue in the fasting state. In order to further evaluate the role of muscle and adipose tissue, we developed methods for analysing LPLA in tissue biopsies6,7. The following presentation will summarise the results of a series of studies aimed at elucidating the regulation of LPLA in these two tissues under different conditions.
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